Ma, Lan

Biocomputational Engineering Assistant Director and Faculty Instructor

Biocomputational Engineering
Fischell Department of Bioengineering

4121 Biomedical Sciences and Engineering, Universities at Shady Grove

B.E.	Huazhong University of Science & Technology, China	Control Engineering
M.S.E.	Johns Hopkins University	Electrical & Computer Engineering
Ph.D.	Johns Hopkins University	Electrical & Computer Engineering

Ph.D.

Thesis title: “Feedback control in the chemotactic pathway of Dictyostelium discoideum”
Thesis advisor: Prof. Pablo A. Iglesias

Journal Publications:

R. Ziraldo and L. Ma. “Computing intrinsic noise of the genetic regulation modeled by Hill functions.” Journal of Computational Systems Biology, 2 (1): 102, 2018.
T. Quarton, K. Ehrhardt, J. Lee, S. Kannan, Y. Li, L. Ma and L. Bleris. “Mapping the operational landscape of microRNAs in synthetic gene circuits.” npj Systems Biology and Applications, 4 (6). doi:10.1038/s41540-017-0043-y, 2018.
R. Moore, H. Ooi, T. Kang, L. Bleris and L. Ma. “'MiR-192-mediated positive feedback loop controls the robustness of stress-induced p53 oscillations in breast cancer cells.” PLoS Computational Biology, 11(12):e1004653. doi:10.1371/journal.pcbi. 1004653, 2015.
R. Ziraldo and L. Ma. “A mathematical model for apoptotic switch in Drosophila.” Physical Biology, 12 (056003). doi:10.1088/1478-3975/12/5/056003, 2015.
R. Ziraldo, N. Link, J. Abrams and L. Ma. “Toward automatic image analysis and assessment of multicellular apoptosis process.” IET Image Processing. doi: 10.1049/iet- ipr.2014.0531, 2014.
L. Ma and R. Ranganathan. “Systems-level characterization of the kernel mechanism of the cyanobacterial circadian oscillator.” Elsevier BioSystems, 117: 30-39, 2014.
H. Ooi and L. Ma. "Modeling heterogeneous responsiveness of intrinsic apoptosis pathway”. BMC Systems Biology, 7:65, 2013.
L. Ma and R. Ranganathan. “Quantifying the rhythm of KaiB-C interaction for in vitro cyanobacterial circadian clock.” PLoS ONE 7(8): e42581. doi:10.1371/journal.pone.00 42581, 2012.
W. Hu, Z. Feng, L. Ma, J. Wagner, J. J. Rice, G. Stolovitzky and A. J. Levine. “A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells.” Cancer Research, 67(6): 2757-65, 2007.
J. Kim, D. G. Bates, I. Postlethwaite, L. Ma and P.A. Iglesias. “Robustness analysis of a molecular network model for oscillations in excitable cells of Dictyostelium”. IEE Systems Biology, 153(3): 96-104, 2006.
J. Wagner, L. Ma, J. J. Rice, W. Hu, A. J. Levine and G. Stolovitzky. “The p53-Mdm2 loop is controlled by a balance of its feedback strength and effective dampening via ATM and delayed feedback.” IEE Systems Biology, 152(3): 109-118, 2005.
L. Ma, J. Wagner, J. J. Rice, W. Hu, A. J. Levine and G. Stolovitzky. “A plausible model for the digital response of p53 to DNA damage.” Proc Natl Acad Sci USA 102 (40): 14266-14271, 2005.
L. Ma, C. Janetopoulos, L. Yang, P. N. Devreotes and P. A. Iglesias. “Two local excitation, global inhibition mechanisms acting complementarily in parallel can explain the chemoattractant-induced PI(3,4,5)P3 response in Dictyostelium.” Biophysical Journal, 87(6): 3764-74, 2004.
C. Janetopoulos, L. Ma, P. N. Devreotes and P. A. Iglesias. “Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton.” Proc Natl Acad Sci USA 101 (24): 8951-6, 2004.
S. Paliwal, L. Ma, J. Krishnan, A. Levchenko, P. A. Iglesias. “Responding to Directional Cues: A Tale of Two Cells.” IEEE Control Systems Magazine 24 (4): 77- 90, 2004.
L. Ma and P. A. Iglesias. “Quantifying robustness of biochemical network models”. BMC Bioinformatics, 3:38, 2002.
L. Ma and Y. Zhang. “Multiobjective genetic algorithm and its application to the design of automatic control system.” (in Chinese) Journal of Systems Engineering and Electronics: pp. 71 – 76, 1997.

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Ma, Lan