Clark Hall: Clark School Innovations | A. James Clark School of Engineering, University of Maryland
SpringTMS™ Total Migraine System

SpringTMS™ Total Migraine System
Robert E. Fischell (M.S. ’53, honorary Sc.D.’95)
Company: eNeura

The SpringTMS device relieves migraine headaches through transcranial magnetic stimulation. The portable device delivers magnetic pulses to the head just seconds a part, resetting the brain’s misfiring neurons. The device is under review by the U.S. Food and Drug Administration, and is already available in Europe.


Improving Football Helmets for Concussion Prevention
Inventors: Laith M. Abu-Taleb, Azam A. Ansari, Dana A. Hartman, Ryan Haughey, David Kuo, Julie R. Loiland, Karan Raje, Afareen Rezvani, and Adam L. Zviman
Company: Guardian Helmets, LLC
This football helmet attachment takes the form of a shock absorber filled with a dilatant fluid, one that thickens under sheer strain, such as the force of a tackle. The simultaneous absorption and transfer of energy from the impact, and the decreased acceleration of the player's head and neck, should result in a dramatic reduction of concussions. The device was innovated by bioengineering students advised by Mechanical Engineering Professor Kenneth Kiger and mentored by Robert E. Fischell for the 2012 Capstone Design Challenge.

Magnetic Syringe
Inventor: Professor Benjamin Shapiro (BioE)
Company: Otomagnetics, co-founded by Didier Depireux (ISR), David Beylin, and Irving Weinberg

Otomagnetics, LLC is developing a method to magnetically deliver drugs and other therapeutic payloads to hard-to-reach targets, such as ear compartments and the eye. This is being considered as a potential minimally-invasive treatment for hearing loss, middle ear infections, and eye conditions.
Drug-Eluting, Expandable Coronary Stent
Inventor: Robert E. Fischell (M.S. ’53, honorary Sc.D.’95)
Company: Svelte Medical Systems, Inc.
Fischell’s innovative coronary stent is mounted on a balloon catheter with an integrated wire to make the implantation of the device easier, safer, and lower cost.

3D-Printed Vascular Grafts
Inventors: Professor John Fisher (BioE) and Anthony Melchiorri
Company: FormaSTEM, founded by John Fisher and Anthony Melchiorri

Fisher and Melchiorri have engineered a polymer-based material resin that is biodegradable, biocompatible and supportive of cell and tissue growth, while degrading over time. Knowing this, FormaSTEM – the company they co-founded – uses this polymer to create vascular grafts, which act as artificial blood vessels and can be replaced by the patient’s own tissue over time.

Implantable Insulin Pump
Inventor: Robert E. Fischell (M.S. ’53, honorary Sc.D.’95)
Company: Medtronic, formerly PaceSetters

The implantable insulin pump provides greater control of insulin delivery for people living with diabetes. The devices lessens the burden of treatment by allowing patients lead a more flexible life, without worrying about strict diet, exercise, and sleep regimens.

Human Factors Research
Mechanical Engineering Assistant Professor Monifa Vaughn-Cooke studies the usability of glucometers and other handheld medical devices for patients with disabilities. Her research aims to identify the behavioral mechanisms associated with system risk propagation to inform the design of user-centric products and systems with the ultimate goal of improving productivity and safety.

Inventor: Associate Professor Ian White (BioE) and Wei W. Yu (Ph.D. ’13, bioengineering)
Company: Diagnostic AnSERS, founded by Eric Hoppmann (Ph.D. ’13, bioengineering), bioengineering graduate student Sean Virgile, and Wei W. Yu

Diagnostic anSERS has developed a novel inkjet printing process to fabricate inexpensive sensors for surface enhanced Raman spectroscopy (SERS), a molecular fingerprinting technique. This technology has the potential to be an excellent, low-cost fit for diagnosis of pathogens, such as hepatitis, tuberculosis, and HIV.


Inventors: Professor Srinivasa Raghavan (ChBE) and Matt Dowling (Ph.D. ’10, bioengineering)
Company: Remedium Technologies, founded by Srinivasa Raghavan and Matt Dowling

Hemogrip is a high-pressure, sprayable foam that can expand into an injured body cavity, adhere to tissue and stop hemorrhaging within minutes during the expansion process.